Evidence for New Fibro Drug Therapies: Options to Take to Your Doctor if Your Current Treatments aren’t Working

Evidence for New Fibro Drug Therapies: Options to Take to Your Doctor if Your Current Treatments aren’t Working

New research into drug therapies helps people with fibromyalgia increase their treatment options. Learning about these new medication options can help you and your doctor finds the best treatment regimen for you.

If you live with fibromyalgia, you know firsthand that one of the primary features of this condition is a lower pain threshold compared to healthy people. There are a number of changes in the body caused by fibromyalgia that increase our sensitivity to pain. One set of changes affects how the spinal cord relays pain sensations from the body to the brain. Several drugs target specific receptors, called NMDA receptors, which are located in deep spinal neurons that carry sensory information to regions in the brain that relate to pain processing. NMDA receptors are activated by signals relayed to the spinal cord by peripheral neurons that sense pressure in muscles, tendons, etc. This type of receptor is activated by the neurotransmitter glutamate. Studies have shown elevated levels of glutamate in the brain and spinal cord of patients with fibromyalgia. There is a strong correlation between elevated glutamate and increased pain in people with fibromyalgia. NMDA receptors can amplify pain signals in patients with fibromyalgia because they are activated to a greater degree by the presence of increased glutamate concentrations in the brain/spinal cord, which trigger pain signals sent to the brain by the deep spinal neurons.

NMDA receptors can be prevented from firing by certain compounds. Two drugs, in particular, seem effective at decreasing NDMDA receptor activation. One is called memantine. Memantine blocks NMDA receptors and decreases glutamate levels. “A randomized, double-blind study in 63 patients with fibromyalgia compared memantine… with placebo over a 6-month period. Compared to placebo there was a significant reduction in pain and pain threshold and improvement in a global function, mood and quality of life”. Memantine was originally developed to treat diabetes, but has also been used to treat dementia; it has been found to also be effective in treating chronic regional pain syndrome.

Click Here to Visit the Store and find Much More….

See also  Retrain Your Brain: My Experience in the Gupta Fibromyalgia Recovery Program

Ketamine is another potent NMDA receptor blocker (yes, the illegal party drug). Studies have shown that it can effectively reduce pain for a subset of fibromyalgia patients “Thus, of 58 patients with fibromyalgia in the above 3 studies, 33 (57%) responded to low dose ketamine (0.3 mg/kg) infusion, as defined by a reduction of pain by 50% or more.” However, studies have not adequately investigated the long-term use of ketamine. However, ketamine has been proven effective in treating chronic regional pain syndrome, which shares many similar characteristics to fibromyalgia.

Another interesting tip focuses on diet changes that can help lower pain levels. Glutamate is found in MSG (monosodium glutamate). Other related compounds, called excitotoxins, like aspartame, can cause harmful over-activity in the brain. “One study showed that 4 weeks of exclusion of monosodium glutamate (MSG), aspartame, and other excitotoxins, resulted in over 30% improvement in fibromyalgia symptoms in 84% of those who completed the diet”.[iv]

What about inflammation and fibromyalgia? A number of studies has found increased levels of pro-inflammatory messengers (called cytokines) in blood collected from FM patients.  A drug called low-dose naltrexone has been investigated for its potential benefits in treating fibromyalgia because of its anti-inflammatory properties. Naltrexone is primarily used to treat opioid overdoses, but when taken at a low dose before bed, studies have found a statistically significant reduction in FM pain compared to the placebo. A recent study found that “after eight weeks of LDN administration, plasma levels of a range of broadly pro-inflammatory cytokines were decreased. In addition, we found that participants reported less pain and symptoms following LDN. Combined, these results support the hypothesis that LDN may help chronic pain conditions, such as fibromyalgia, by acting as an atypical anti-inflammatory medication”. Pain reduction was found to be 15% and symptom reduction 18%. While these results are modest, for many FM patients desperate for options, low-dose naltrexone could be a valuable part of their treatment regimen.

Click Here to Visit the Store and find Much More….

See also  How Gluten Intolerance Can Aggravate Fibromyalgia

References:

Fibro Women Blogs

Click here to Get the latest Fibro Women Updates

Click here to Get the latest Fibromyalgia Caring Updates

Click here to Get the latest Women with Fibromyalgia Updates

Click here to Get the latest Chronically Ill Updates

Chronic Woman Blogs

Click here to Get the latest Chronic Woman Updates

Click here to Get the latest Fibromyalgia Home Updates

Click here to Get the latest Fibro Mom Blog Updates

Click here to Get the latest Fibromyalgia Journey Updates

Click here to Get the latest Fibromyalgia Resources Updates

Chronic Illness Blogs

Click here to Get the latest Chronic illness Updates

Click here to Get the latest Chronic Cure Updates

Click here to Get the latest Chronic Health Updates

Click here to Get the latest Fibro Warrior Updates

Click here to Get the latest Fibromyalgia Awareness Updates

Official Fibromyalgia Blogs

Click here to Get the latest Healthizes Updates

Click here to Get the latest Fibromyalgia Center Updates

Click here to Get the latest Fibromyalgia Updates

Click here to Get the latest Chronic Illness updates

Fibromyalgia Stores

Click here to Visit Fibromyalgia Store

Click here to Visit Disability Store

Click here to Visit Fibromyalgia Shop

Click here to Visit Fibromyalgia Showroom

Fibromyalgia Social

Click here to Visit Fibromyalgia Facebook Page

Click here to Visit Fibromyalgia Facebook Group

Click here to Visit Fibromyalgia Instagram Page

Click here to Visit Fibromyalgia Youtube Channel

Click here to Visit Fibromyalgia Tiktok Page

Click here to Visit Fibromyalgia Twitter Page

Click here to Visit Fibromyalgia Quora Community

See also  I Survived The Flare - Fibromyalgia

Click here to Visit Fibromyalgia Pinterest Board

Fibromyalgia Home - Coping with Fibromyalgia in-home Fibromyalgia Treatments -Fibromyalgia Symptoms - Fibromyalgia Diagnosis - Fibromyalgia Cure - Fighting and coping with fibromyalgia

Leave a Reply